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The most important serious side effects include acute pancreatitis (severe persistent abdominal pain radiating to the back, though clinical trials found similar pancreatitis rates to comparators), severe dehydration from persistent vomiting or diarrhea (signs include dizziness, decreased urination, extreme thirst), gallbladder disease including cholecystitis or cholelithiasis (right upper quadrant pain, fever, jaundice), severe allergic reactions (difficulty breathing, swelling of face or throat), and severe hypoglycemia when combined with insulin or sulfonylureas (confusion, loss of consciousness, seizures)

[Texas flood disaster: Harvey has unloaded 9 trillion gallons of water] Officials said Houston, a major center for the nation's energy industry, had suffered billions of dollars in damage and would take years to fully recover

[DOI] [PMC free article] [PubMed] [Google Scholar] 95.Seitz G., Bonin M., Fuchs J., Poths S., Ruck P., Warmann S.W., Armeanu-Ebinger S

It inhibits tyrosinase activity that reduces the concentration of eumelanin, responsible for skin dullness