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Metabolomic Analysis of Schizosaccharomyces pombe: Sample Preparation, Detection, and DataInterpretation

Using the human ALS-linked superoxide dismutase 1 (SOD1 G93A ) mutant gene to replicate ALS in mice further highlighted the primary role of astrocyte: astrocyte-selective silencing of SOD1 alleviated ALS symptoms and increased life span 240,241 , whereas restricted expression of SOD1 in neurons did not cause pathology 242,243

Sleep deprivation induces upregulation of the main Cl-accumulating transporter, NKCC1/SLC12A2, resulting in increased neuronal Cl accumulationa reversible process modified by the NKCC1 inhibitor bumetanide 107

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