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Evaluation of the Incretin Effect in Humans Using GIP and GLP-1 Receptor Antagonists

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Although these changes in HR upon GLP-1 RA administration were subtle and the underlying mechanisms are unclear, further studies are necessary to elucidate the long-term effects of GLP-1 RAs primarily on HR and other related variables to clarify whether the elevated HR can be regarded as a transient reflex mechanism or whether it might in fact lead to poor cardiovascular outcomes in a diabetic population

Dipeptidyl peptidase-4 inhibitors DPP-4 is a part of the serine protease family that is found in two membrane-bound and soluble forms in various tissues such as the heart, lung, kidney and liver