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Importantly, this resistance was significantly reduced by RNAi-mediated suppression of genes involved in multiple aspects of autophagy, including autophagy initiation ( unc-51/ATG1 ), membrane nucleation ( bec-1/ATG6 ), phosphoinositide 3-phosphate binding ( atg-18 ) and autophagosome elongation ( lgg-1/ATG8 ) (Fig

Recently, it has been found that miR-205 deregulates lipid metabolism in hepatocellular carcinoma by targeting acyl-CoA synthetase ACSL1, a lipid metabolism enzyme in liver 95
